In New York, when the shy and lonely project manager of a design firm Matt Saunders (Luke Wilson) meets Jenny Johnson (Uma Thurman) in the subway, he invites her to date and have dinner with him. Jenny immediately falls in love for him, they have sex and she discloses her true identity to him, telling that she is the powerful superhero G-Girl. After meeting his co-worker and friend Hannah Lewis (Anna Faris), the needy Jenny becomes jealous, controlling and manipulative, and Matt follows the advice of his best friend Vaughn Haige and dumps her, breaking her heart. Jenny turns Matt's life into hell, while he has a romance with Hannah. However, the archenemy of G-Girl and former high school sweetheart of Jenny, Professor Bedlam, proposes Matt to lure Jenny to strip her superpowers.

BVLGARI Store, 730 5th Avenue and West 57th Street, Manhattan.

342-348 East 54th Street (btw 1st and 2nd Avenues) Manhattan.

Subway Entrance, Franklin Street and Varick Street, Manhattan.

Matt's Apartment, 127 East 10th Street and 2nd Avenue, Manhattan.

2nd Avenue and East 10th Street, Manhattan.

The Central Bar, 109 East 9th Street and 3rd Avenue, Manhattan.

Matt's Workplace, 255 Park Avenue and East 18th Street, Manhattan.

Odeon Restaurant, 145 West Broadway and Thomas Street, Manhattan.

Statue of Liberty, Liberty Island, New York Harbor.

Times Square (Broadway, 7th Avenue, West 42nd and 47th Streets) Manhattan.