After ten long years, grown-up best friends since college, Jess (Scarlett Johansson), Alice (Jillian Bell), Frankie (Ilana Glazer) and Blair (Zoë Kravitz) reunite, as Jess who is running for state senator, is about to walk the aisle with her fiancé, Peter. Without delay and with the help of Jess' BFF, Alice, everything is ready for a fabulous once-in-a-lifetime bachelorette weekend in sun-drenched Miami to relive those glorious college days of the past, starting off from the city's trendy nightclubs along with a new free-spirited Aussie friend, Pippa. Under those circumstances and as the night is still young, the girls will order a male stripper from Craigslist for the soon-to-be bride, unfortunately, however, in the heat of the moment, they will accidentally kill him. Now, things are bound to take a turn for the worse, nevertheless, there is no case, if there is no body.