The turtles face a new challenge when Shredder escapes from custody and joins forces with Baxter Stockman, a mad scientist who plans to use a serum to take over the world. Along for the ride are Bebop and Rocksteady, two dimwitted henchmen who provide plenty of muscle. Luckily, the turtles have their own allies in April O'Neil (Megan Fox), Vernon Fenwick (Will Arnett) and Casey Jones (Stephen Amell), a hockey-masked vigilante. As the pizza-loving heroes prepare for battle, the notorious Krang also emerges to pose an even greater threat.

Madison Square Garden, 8th Avenue and West 33rd Street, Manhattan.

Grand Central Terminal, 89 East 42nd Street and Park Avenue, Manhattan.   Grand Central is a commuter rail terminal station at 42nd Street and Park Avenue. Built by and named for the New York Central Railroad in the heyday of American long-distance passenger rail travel, it is the largest train station in the world by number of platforms.

Vazac's Horseshoe Bar, 108 East 7th Street and Avenue B, Manhattan.   Vazak's Bar has also been featured in Crocodile Dundee and Godfather Part II.

TCRI HQ, 6th Avenue and 42nd Street, Manhattan.   The Bank of America Tower at One Bryant Park is a 1,200 ft skyscraper in the Midtown area of Manhattan in New York City. It is located on Sixth Avenue, between 42nd and 43rd Streets, opposite Bryant Park.

East 42nd Street and 6th Avenue, Manhattan.

Cortlandt Alley (btw Walker Street and White Street) Manhattan.

Jane's Carousel, Brooklyn Bridge Park, Dock Street, Brooklyn.   Jane's Carousel is a carved, wooden, 48-horse carousel that was built in 1922 for the Idora Park amusement park in Youngstown, Ohio by the Philadelphia Toboggan Company.

185 West Broadway and Leonard Street, Manhattan.

Staple Street (btw Jay Street and Harrison Street) Manhattan.

Times Square, Manhattan.   Times Square is a major commercial intersection, at the junction of Broadway and Seventh Avenue and stretching from West 42nd to West 47th Street.

Statue of Liberty, Liberty Island, New York Harbor.   The Statue of Liberty is a colossal neoclassical sculpture on Liberty Island in New York Harbor, designed by Frédéric Bartholdi and dedicated on October 28, 1886.