Emily Taylor (Rooney Mara), despite being reunited with her husband from prison, becomes severely depressed with emotional episodes and suicide attempts. Her psychiatrist, Jonathan Banks (Jude Law), after conferring with her previous doctor, eventually prescribes an experimental new medication called Ablixa. The plot thickens when the side effects of the drug lead to Emily killing her husband in a "sleepwalking" state. With Emily plea-bargained into mental hospital confinement and Dr. Banks' practice crumbling around him, the case seems closed. However, Dr. Banks (Catherine Zeta-Jones) cannot accept full responsibility and investigates to clear his name. What follows is a dark quest that threatens to tear what's left of his life apart even as he discovers the diabolical truth of this tragedy.

Le Cirque, 151 East 58th Street and 3rd Avenue, Manhattan.

High Line Park, 519 West 23rd Street, Meatpacking District, Manhattan.

Subway, Franklin Street and West Broadway, Manhattan.

Funeral Chapel, 1076 Madison Avenue and East 81st Street, Manhattan.

East Bay Diner, 491 1st Avenue and East 29th Street, Manhattan.

St Luke's School, 487 Hudson Street and Grove Street, Manhattan.

Bellevue Hospital Center, 1st Avenue and East 26th Street, Manhattan.

Jonathan's Apartment, 381 Broome Street and Mott Street, Manhattan.