When the evil wizard Gargamel (Hank Azaria) chases the tiny blue Smurfs Papa Smurf (Jonathan Winters), Smurfette (Katy Perry), Clumsy (Anton Yelchin), Grouchy (George Lopez), Brainy (Fred Armisen) and Gutsy (Alan Cumming) out of their village, they tumble from their magical world and into the real world of Central Park and New York City. The Smurfs befriend Patrick (Neil Patrick Harris) and Grace Winslow (Jayma Mays), a married and expectant couple and up staying in their apartment until they find a way to get back to their village before Gargamel tracks them down.

Boathouse, Prospect Park, Brooklyn.

Pond (Near Gapstow Bridge) Central Park, Manhattan.

Winslow's Apartment, 111 East 7th Street (btw 1st Avenue & Avenue A) Manhattan.

The Mall, Central Park, Manhattan.

Belvedere Castle, Central Park, Manhattan.

East 42nd Street and 6th Avenue, Manhattan.

Rockefeller Center, 5th Avenue (btw West 49th and 50th Streets) Manhattan.   Rockefeller Center Rockefeller Center is a complex of 19 commercial buildings covering 22 acres (89,000 m2) btw 48th and 51st streets in New York City, United States. Built by the Rockefeller family, it is located in the center of Midtown Manhattan, spanning the area btw Fifth Avenue and Sixth Avenue. It was declared a National Historic Landmark in 1987.

otsoNY Comments: In this scene, Gargamel throws a plate with bread up in the air with the cat, it falls and a breaking sound is heard. However, seconds later, the plate and the bread are on the same place as if untouched!

The Russian Tea Room, 150 West 57th Street and 7th Avenue, Manhattan.

FAO Schwarz (Toy Store) 767 5th Avenue and East 59th Street, Manhattan.

Times Square (Broadway, 7th Avenue, West 42nd and 47th Streets) Manhattan.

Cortlandt Alley and Walker Street, Manhattan.

Housing Works Bookstore Cafe, 126 Crosby Street and Prince Street, Manhattan.

Columbus Circle and Central Park West, Manhattan.